Curriculum vitae - Szilágyi Tibor PhD

Competence and results

Electrophysiology of the cerebral cortex - physiological, anatomical and pharmacological properties of different types of interneurons in the rat hippocampus and cat visual cortex, in vitro study of synaptic interaction between two intracellularly recorded neurons, study of the interneuronal cooperation and function of the basic cortical circuit, dendritic integration and the role of inhibition in cortical circuits, correlated anatomical and electrophysiological study of the rat hippocampal interneurons.

Quantal analysis - experimental and theoretical analysis of the statistic nature of the synaptic transmission in the visual cortex.

Computer modelling - Using and developing GENESIS (GEneral NEural SImulation System), described the effects of dendritic morphology on nerve functions, importance of stratification of excitatory nerve path, different effect of synaptic input arriving on different functional domains of the dendritic tree, theoretical demonstration of the imposibility of adequate voltage-clamp in distal dendrites of hippocampal pyramidal cells, analysis of factors influencing the coincidence detection and temporal summation functioning mode of neurons.

Programming in Pascal/Delphi, software development:
- electrophysiolgical data acquisition program, used at the Medical Research Council - Anatomical Neuropharmacology Unit (MRC-ANU), Oxford,
- program for electrophysiological data processing
- program for processing of data obtained by computer modelling, used at the Theoretical Neurobiology Unit, University of Antwerp, Belgium
- image processing software for electronmicroscopic images, used athe Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
-statistical program for analysing some immunohistochemical data, used at the MRC-ANU, Oxford.

Selected publications

• Buhl, E.H., Szilágyi, T., Halasy, K. & Somogyi, P. (1996) Physiological Properties of Anatomically Identified Basket and Bistratified Cells in the CA1 Area of the Rat Hippocampus In Vitro. Hippocampus, 6, 294-305.
• Buhl, E.H., Tamás, G., Szilágyi, T., Stricker, C., Paulsen, O. & Somogyi, P. (1997) Effect, number and location of synapses made by single pyramidal cells onto aspiny interneurones of cat visual cortex. J Physiol, 500.3, 689-713.
• Szilágyi, T. & Lőrinczi, Z. (2003) Modelarea computerizată a unor interneuroni din hipocampul de şobolan. (Computer modelling of some interneurons of the rat hippocampus) Revista de Medicină şi Farmacie - Orvosi és Gyógyszerészeti Szemle, 49, 111-118.
• Szilágyi, T. & De Schutter, E. (2004) Effects of variability in anatomical reconstruction techniques on models of synaptic integration by dendrites: a comparison of three internet archives. European Journal of Neuroscience, 19, 1257-1266.
• Szilágyi, T. & Metz, J. (2005) Modelarea potenţialelor extracelulare din hipocampul de şobolan. (Computer modeling of extracellular potentials in the rat hippocampus) Revista de Medicină şi Farmacie - Orvosi és Gyógyszerészeti Szemle, 51, 267-273.
• Élettan: az idegrendszer (Physiology: the nervous system), 2005, University Press - Tg. Mureş, ISBN 973-7788-58-3.

Research collaborations:

• Biological Research Center of the Hungarian Academy of Sciences Molecular Neurobiology Workgroup, Szeged, Ungaria: oct. 1992 - aug. 1993, principal investigator: Arpad Parducz

• Medical Research Council, Anatomical Neuropharmacology Unit, Oxford, Anglia: apr. 1994 - sept. 1994, iun. 1995 - aug. 1995, iul. 1996-sept. 1996, feb.1998, apr. 1998, iun. 1999, iun. 2006, principal investigators: Peter Somogyi, Eberhard Buhl

• University of Antwerp - UIA, Department of Medicine, Theoretical Neurobiology, Antwerp, Belgia: feb. 1998-mar. 1998, iul., nov. 1999, febr., jul., nov. 2000, febr., oct. 2001, febr., iul.-aug., nov. 2003, sept. - dec. 2004, principal investigator: Erik De Schutter.